TRK* fusion proteins are often a primary oncogenic driver across multiple tumors in adults and children1,2
- In TRK fusion cancer, the NTRK a gene fuses with an unrelated gene, causing overexpression of the TRK protein2-4
- NTRK gene fusions may be mutually exclusive of other known oncogenic drivers5,6
- The presence of TRK proteins has been associated with more aggressive cancer in some tumor types, highlighting an unmet medical need among TRK fusion cancer patients7-9
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