The NTRK a gene family encodes
the TRK* family of proteins1-3
NTRK gene fusion is caused by
NTRK gene fusions cause the
overexpression of TRK proteins1
TRK fusion proteins are
*TRK, tropomyosin receptor kinase.
aNTRK, neurotrophic receptor tyrosine kinase.
References: 1. Amatu A, Sartore-Bianchi A, Siena S. ESMO Open. 2016;1(2):e000023. 2. Vaishnavi A, Le AT, Doebele RC. Cancer Discov. 2015;5(1):25-34. 3. Uren RT, Turnley AM. Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player [published online ahead of print May 14, 2017]. Front Mol Neurosci. 2014;7(39). doi:10.3389/fnmol.2014.00039. 4. Kumar-Sinha C, Kalyana-Sundaram S, Chinnaiyan AM. Landscape of gene fusions in epithelial cancers: seq and ye shall find. Genome Med. 2015;7:129. doi:10.1186/s13073-015-0252-1. 5. Mertens F, Antonescu CR, Mitelman F. Gene fusions in soft tissue tumors: recurrent and overlapping pathogenic themes. Genes Chromosomes Cancer. 2016;55(4):291-310. 6. Latysheva NS, Oates ME, Maddox L, et al. Molecular principles of gene fusion mediated rewiring of protein interaction networks in cancer. Mol Cell. 2016;63(4):579-592. 7. Mahajan K, Mahajan NP. Cross talk of tyrosine kinases with the DNA damage signaling pathways. Nucleic Acids Res. 2015;43(22):10588-10601. 8. Nanda N, Fennell T, Brandhuber B, Tuch BB, Low JA. Identification of tropomyosin kinase receptor (TRK) point mutations in cancer. Poster presented at: Annual Meeting of the American Society of Clinical Oncology; May 29-June 2, 2015; Chicago, IL. Abstract 1553. 9. Yang L, Lee M-S, Lu H, et al. Analyzing somatic genome rearrangements in human cancers by using whole-exome sequencing. Am J Hum Genet. 2016;98(5):843-856. 10. Stransky N, Cerami E, Schalm S, Kim JL, Lengauer C. The landscape of kinase fusions in cancer. Nat Commun. 2014;5:4846. doi:10.1038/ncomms5846. 11. Eisenberg E, Levanon EY. Human housekeeping genes, revisited. Trends Genet. 2013;29(10):569-574. 12. U.S. National Library of Medicine. Genetics Home Reference: TPM3 gene. https://ghr.nlm.nih.gov/gene/TPM3. Updated February 20, 2018. Accessed February 22, 2018. 13. U.S. National Library of Medicine. Genetics Home Reference: TRIM24 gene. https://ghr.nlm.nih.gov/gene/TRIM24. Updated February 20, 2018. Accessed February 22, 2018. 14. U.S. National Library of Medicine. Genetics Home Reference: ETV6 gene. https://ghr.nlm.nih.gov/gene/ETV6. Updated February 20, 2018. Accessed February 22, 2018.